Racemisation process

Details Racemisation process Racemisation process

1997-02-07

1998-10-13

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558354, C07C25524, C07D21188

Patent

active

058213694

ABSTRACT:
A process for the racemization of an enantiomerically-enriched compound of formula (3), comprises treatment of enantiomerically-enriched (3) with a base to obtain anion (4), optionally in protonated form, which is then combined with CH.sub.2 =CH--Y.sup.1 to form racemic (3), ##STR1## wherein Ar=aryl or heteroaryl; Ak=C.sub.1-20 alkyl; X=CN, CO.sub.2 R, CONR.sup.1 R.sup.2, and COR; Y and Y.sup.1 are independently selected from CN, CO.sub.2 R, CONR.sup.1 R.sup.2 and R, R.sub.1 and R.sub.2 are independently selected from H and C.sub.1-20 alkyl; optionally as a salt thereof.
This racemization process can be used as part of an efficient synthesis of enantiomerically-enriched verapamil or aminoglutethimide.

REFERENCES:
patent: 2848455 (1958-08-01), Hoffman et al.

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