Racemates of 3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy

Details Racemates of 3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy Racemates of 3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy

1985-02-28

1988-02-23

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549399, A61K 3135, C07C31164

Patent

active

047270853

ABSTRACT:
A novel racemate K-351A composed of an optical isomer (2'S),(3S)K-351 [3,4-dihydro-8-(2'-hydroxy-3'-isopropylamino)propoxy-3-nitroxy-2H-1-benzop yran] and (2'R),(3R)K-351, a novel racemate K-351B composed of an optical isomer (2'R),(3S)K-351 and (2'S),(3R)K351 and an acid addition salt of these two novel racemates; a process for converting the two racemates to each other; and also to a pharmaceutical composition comprising each of the two racemates useful for the treatment of cardiovascular diseases.

REFERENCES:
patent: 4394382 (1983-07-01), Shiratsuchi et al.

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