Rabies vaccine

Details Rabies vaccine Rabies vaccine

1984-07-10

1987-03-10

Kight, John

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 435235, 435238, A61K 39205

Patent

active

046490493

ABSTRACT:
A rabies vaccine composition is disclosed which comprises a sterilized suspension of proteineous suckling mice or rat brain particles of injectable particle size laden with an amount of inactivated rabies virus which is equivalent to a virus titer of at least 10.sup.5.0 to about 10.sup.6 MLD.sub.50 per 0.1 milliliter thereof at a brain tissue concentration of from about 0.3% to about 5.0% by weight, in physiological buffer solution having a pH of between about 7.5 and about 8.0 and comprising an amount dissolved therein, of between 0.02 and 0.08, preferably 0.04, moles per liter, of a buffer composition comprising a mixture of an organic base formula ##STR1## wherein R.sub.1 and R.sub.2 each are CH.sub.2, C.sub.2 H.sub.4 or C.sub.3 H.sub.6, preferably C.sub.2 H.sub.4 combined with between 0.03 and 0.12, preferably 0.06 moles per liter of its corresponding salt, preferable sodium salt. The presence of ethylene maleic anhydride enhances the effectiveness of the composition. The vaccine composition exhibits a high potency and its pH value remains stable over a prolonged period of time.

REFERENCES:
patent: 4252792 (1981-02-01), Blades
patent: 4584194 (1986-04-01), Bass et al.
CA. No. 1190x, vol. 75, 1971, Substitution of HEPES for Bicarbonate . . . Cells, Melzon et al.
CA. No. 74524a, vol. 85, 1976, The Effects of HEPES Buffer . . . Thrombokinase, Roberts.

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