Rabconnectin-3-binding protein

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07153831

ABSTRACT:
A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an anti-Rab3A GEP antibody, a protein participated in the regulation of activation or inactivation of Rab3A is determined. As the protein binds to rabconnectin-3 and GDP/GTP exchange protein, it can be used for screening for a material that increases or decreases the binding.

REFERENCES:
patent: 0 856 583 (1998-08-01), None
patent: 10-276783 (1998-10-01), None
patent: 2001-309733 (2001-11-01), None
patent: WO 01/66739 (2001-09-01), None
Tanaka, et al., “Role of Rab3 GDP/GTP Exchange Protein in Synaptic Vesicle Trafficking at the Mouse Neuromuscular Junction”,Molecular Biology of the Cell, 12: 1421-1430, 2001.
Wada, et al., “Isolation and Characterization of A GDP/GTP Exchange Protein Specific for the Rab3 Subfamily Small G Proteins”,The Journal of Biological Chemistry, 272(7): 3875-3878, 1997.
Yamaguchi, et al., “A GDP/GTP Exchange Protein for the Rab3 Small G Protein Family Up-Regulates a Postdocking Step of Synaptic Exocytosis in Central Synapes”,PNAS, 99(22): 14536-14541, 2002.
GenBank Accession No. AB011113, 1998.
GenBank Accession No. AC007052, 1999.
GenBank Accession No. AC008006, 2001.
GenBank Accession No. AF305813, 2000.
GenBank Accession No. XM028588, 2002.
Nagano, et al., “Molecular Cloning and Characterization of the Noncatalytic Subunit of the Rab3 Subfamily-Specific GTPase-Activating Protein”,The Journal of Biological Chemistry, 273(38): 24781-74785, 1998.
Nagano, et al., “Rabconnectin-3, a Novel Protein that Binds Both GDP/GTP Exchange Protein and GTPase-Activating Protein for Rab3 Small G Protein Family”,The Journal of Biological Chemistry, 277(12):9629-9632, 2002.
Nakanishi, et al., “Isolation of Regulatory Proteins for the Rab3 Subfamily GTPases”,Methods in Molecular Biology, 189: 143-157, 2002.
Oishi, et al., “Localization of the Rab3 Small G Protein Regulators in Nerve Terminals and Their Involvement in Ca2+—Dependent Exocytosis”,The Journal of Biological Chemistry, 273(51): 34580-34585, 1998.
Sanders, et al., “Assignment of WDR7 (Alias TRAG, TGF-β Resistance Associated Gene) to Orthologous Regions of Human Chromosome 18q21.1→q22 and Mouse Chromosome 18D.1-E.3 by Fluorescence in Situ Hybridization”,Cytogenet Cell Genet, 88: 324-325, 2000.

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