Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-01-23
2009-12-08
Haddad, Maher M (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S388240
Reexamination Certificate
active
07629131
ABSTRACT:
The present invention relates to a rabbit monoclonal antibody that binds to human Id3 protein and/or mouse Id3 protein with high specificity and high affinity. The antibody has a binding constant, measured with respect to human Id3 protein or mouse Id3, of greater than 1×108/molar. The antibody has no substantial cross-reactivity to other family Id proteins such as Id1, Id2, or Id4, or other endogenous proteins present in the cells that express Id3 protein. The specificity and high affinity of the rabbit monoclonal antibodies of the present invention allows sensitive and specific detection and/or quantitation of human or mouse Id3 protein in biological samples. The antibodies are useful in immunochemical-based assays such as ELISA, western blot, and immunohistochemical staining.
REFERENCES:
patent: 5654188 (1997-08-01), Ellmeier et al.
patent: 5675063 (1997-10-01), Knight
patent: 5939272 (1999-08-01), Buechler et al.
patent: 7370021 (2008-05-01), Reeve et al.
patent: 2003/0023995 (2003-01-01), Benezra
patent: 2003/0152921 (2003-08-01), Edwards et al.
Forrest et al., “Intron Retention Generates a Novel Id3 Isoform That Inhibits Vascular Lesion Formation”, The Journal of Biological Chemistry, Jul. 2004, vol. 279, No. 31, pp. 32897-32903, see abstact and p. 32899.
Matsumura et al., “Vascular Injury Induces Posttranscriptional Regulation of the Id3 Gene: Cloning of a Novel Id3 Isoform Expressed During Vascular Lesion Formation in Rat and Human Atheroschlerosis”, Arterioschlerosis, Thrombosis, and Vascular Biology, May 2001, vol. 21, pp. 752-758.
Chen Jung-Shou
Garland William A.
Angiogenex, Inc.
Biocheck, Inc.
Haddad Maher M
Howrey LLP
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