Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-12-03
2000-01-18
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 4353201, 536 231, C12Q 168, C12P 2106, C07H 2102
Patent
active
060156724
ABSTRACT:
The invention provides a human Rab-specific guanine-nucleotide dissociation inhibitor (RGDI) and polynucleotides which identify and encode RGDI. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of RGDI.
REFERENCES:
Khosravi-Far, R. et al., "Isoprenoid modification of rab proteins terminating in CC or CXC motifs", Proc. Natl. Acad. Sci. USA, 88:6264-6268, (1991).
Sanford, J.C. et al., "GDP Dissociation Inhibitor Serves as a Cytosolic Acceptor for Newly Synthesized and Prenylated Rab5", J. Biol. Chem., 270:26904-26909, (1995).
Janoueix-Lerosey, I. et al., "Two-hybrid System Screen with the Small GTP-binding Protein Rab6", J. Biol. Chem., 270:14801-14808, (1995), (GI 722666; GI 722667).
Wu, S.K. et al., "Structural insights into the function of the Rab GDI superfamily", Trends Biochem. Sci., 21:472-476 (1996).
Janoueix-Lerosey, I. et al., (Direct Submission), GenBank Sequence Database (Accession 722667), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 722666; GI 722667).
Janoueix-Lerosey, I. et al., (Direct Submission), GenBank Sequence Database (Accession L40934), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 722666; GI 722667).
Soares, M.B. et al., "Construction and characterization of a normalized cDNA library", Proc. Natl. Acad. Sci. USA, 91:9228-9232, (1994).
Bonaldo, M.F. et al, "Normalization and Subtraction: Two Approaches to Facilitate Gene Discovery", Genome Res., 6:791-806, (1996).
Zalcman, G. et al., "RhoGDI-3 Is a New GDP Dissociation Inhibitor (GDI)", J. Biol. Chem., 271:30366-30374, (1996).
NCI-CGAP. Est submitted in Genebank, accession number AA581889, Sep. 26, 1997.
Corley Neil C.
Lal Preeti
Yue Henry
Hutzell Paula K.
Incyte Pharmaceuticals Inc.
Price Leanne C.
Sun-Hoffman Lin
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