Rab Proteins

Details Rab Proteins Rab Proteins

1997-08-21

1999-04-06

Huff, Sheela

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 530350, 435 6, 4353201, 435 691, C07H 2102, C07H 2100

Patent

active

058920129

ABSTRACT:
The invention provides three human Rab proteins (RABP) and polynucleotides which identify and encode RABP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of RABP.

REFERENCES:
Novick, P. and P. Brennwald, "Friends and Family: The Role of the Rab GTPases in Vesicular Traffic", Cell, 75: 597-601 (1993).
Khosravi-Far, R. et al., "Isopresnoid modification of rab proteins terminating in CC or CXC motifs", Proc. Natl. Acad. Sci. USA, 88: 6264-6268 (1991).
Zahraoui, A., et al., "The Human Rab Genes Encode a Family of GTP-binding Proteins Related to Yeast and SEC 4 Products Involved in Secretion", J. Biol. Chem., 264: 12394-12401 (1989).
Brauers, A. et al., "Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini", Eur. J. Biochem., 237: 833-840 (1996) (GI 1154900; GI 1154901).
Olkkonen, V.M. et al., "Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily", J. Cell Sci., 106: 1249-1261 (1993) (GI 438163; GI 438164).
Fridell, R.A. et al., "Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export of late HIV-1mRNAs occurs via a cellular protein export pathway", Proc. Natl. Acad. Sci. USA, 93: 4421-4424 (1996).
Seabra, M.C. et al., "Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase", Science, 259: 377-381 (1993).
Tuomikosik, T. et al., "Inhibition of endocytic vesicle fusion in vitro by the cell-cycle control protein kinase cdc2", Nature, 342: 942-945 (1989).
Olkkonen, V.M. et al., (Direct Submission), GenBank Sequence Database (Accession Z22819), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 438163; GI 438164).
Vielh, E. et al., (Direct Submission), GenBank Sequence Database (Accession X13905), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 57005; GI 57006).
Vielh, E. et al., "Nucleotide sequence of a rat cDNA: RAB1B, encoding a RAB1-YPT related protein", Nucl. Acids Res., 17: 1770 (1989) (GI 57005L GI 57006).
Brauers, A. et al., (Direct Submission), GenBank Sequence Database (Accession X78606), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1154900; GI 1154901).
Ren, M. et al., "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase", Proc. Natl. Acad. Sci. USA, 93: 5151-5155 (1996).

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