RAB protein

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 4, 435 911, 435 912, 435 691, C12Q 168

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active

060108592

ABSTRACT:
The present invention provides a human novel RAB protein (SRAB) and polynucleotides which identify and encode SRAB. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of SRAB.

REFERENCES:
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Khosravi-Far, R., et al., "Isoprenoid modification of rab proteins terminating in CC or CXC motifs", Proc. Natl. Acad. Sci. USA,88: 6264-6268 (1991).
Wagner, A.C.C., et al., "Molecular cloning of a new member of the rab protein family, rab 26, from rat pancreas", Biochemical and Biophysical Research Communications, 207 (3): 950-956 (1995).
Matteoli, M., et al., "Association of Rab 3A with Synaptic Vesicles at Late Stages of the Secretory Pathway", The Journal of Cell Biology, 115: 625-633 (1991).
Fridell, R., et al., "Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway", Proc. Natl. Acad. Sci. USA, 93: 4421-4424.
Seabra, M.C., et al., "Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase", Science, 259: 377-381 (1993).
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Mindong, R., et al., "In its active form, the GTP-binding protein rab8 interacts with a stress-activated kinase", Proc. Natl. Acad. Sci. USA, 93: 5151-5155.
Wagner, A.C., et al., (GI 619734) GenBank Sequence Database (Accession U18771), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084 (1995).
Wagner, A.C. et al., (GI 619733) GenBank Sequence Database (Accession U18771), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084 (1995).
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Nimmo, E.R., et al., (GI 234745) GenBank Sequence Database (Accession S53268), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084 (1992).
Saxe, S.A. and A.R. Kimmel, "SAS1 and SAS2, GTP-Binding Protein Genes in Dictyostelium discodeum with Sequence Similarities to Essential Genes in Saccharomyces cerevisiae", Mol. Cell. Biol., 10:2367-2378 (1990).
Saxe, et al., GenBank Sequence Database (GenBank Accession B34716, B61571), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 2084 (1995).
Reeck, G.R. et al., "Homology In Proteins and Nucleic Acids: A Terminology Muddle and a Way out of it", Cell, 50: 667 (1987).
Bogerd, H.P et al., "Identification of a Novel Cellular Cofactor for the Rev/Rex Class of Retroviral Regulatory Proteins", Cell, 82: 485-494 (1995).
EMBL Database entry T08521; Accession number T08521; Aug. 6, 1993; Adams et al.: `Rapid cDNA Sequencing from a directionally cloned human infant brain cDNA library.` XP002072108.
EMBL Database entry HS132292; Accession number N48132; Feb. 18, 1996; Hiller et al.: `The WashU-Merck EST project.` XP002072117.
EMBL Database entry HSR88060, Accession number R88060; Oct. 10, 1995; Hiller et al.: "The WashU-Merck EST project." XP002072109.
Wagner et al. (1995) Molecular Cloning of a New Member of the RAB Protein Family, RAB 26, From Rat Pancreas. Biochem. Biophys. Res. Comm. 207/3:950-956, Feb. 1995.
Maniatis et al. (1982) Molecular Cloning A Laboratory Manual. Cold Spring Harbor Laboratory. pp. 324-333.
Wagner et al. (1995) GenBank Database, Accession No. U18771. Rattus Norvegicus Rab26 mRNA, Complete cds.
Wagner et al. (1995) GenBank Database, Accession No. JC2528. Rab protein 26-Rat.

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