Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-06-05
2007-06-05
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C540S458000, C548S138000, C548S208000
Reexamination Certificate
active
11186425
ABSTRACT:
Rifamycin derivatives having the following structure of general formula I (both hydroquinone and corresponding quinone (C1-C4) forms):or its salts, hydrates or prodrugs thereof; wherein a preferred R1comprises hydrogen or acetyl and a prefered R2comprises hydrogen, methyl or other lower alkyls; wherein asterik (*) denotes the carbon bearing the chiral center, wherein absolute configuration is assigned as R or S. Methods of preparation of the aforementioned rifamycin derivatives are also described. The compounds exhibit antimicrobial activities, including activities against drug-resistant microorganisms.
REFERENCES:
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patent: WO 2005/070940 (2005-08-01), None
patent: WO 2005/070941 (2005-08-01), None
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PCT Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, or the Declaration. Dec. 12, 2005.
Combrink Keith D.
Ding Charles Z.
Harran Susan
He Yong
Jin Yafei
Cumbre Pharmaceuticals Inc.
Jackson Walker L.L.P.
Kifle Bruck
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