Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-07-11
2006-07-11
Dentz, Bernard (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C549S317000, C549S292000, C546S238000, C560S051000, C560S056000, C560S100000, C560S102000, C560S112000, C514S532000, C514S545000, C514S544000
Reexamination Certificate
active
07074826
ABSTRACT:
The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in treating a disease or illness in a mammal. To this end, a composition comprising a compound mentioned above, or a pharmaceutically acceptable salt thereof where salt formation occurs, is administered to the mammal in an amount sufficient to elicit a chemopreventative effect or a chemoprotective effect or a therapeutic effect or a prophylactic effect.
REFERENCES:
patent: 5981592 (1999-11-01), Wechter et al.
patent: 2003/0027867 (2003-02-01), Zavitz
patent: 0 305 089 (1989-03-01), None
Wechter et al, Cancer Research,vol. 60, p. 2203-2208, Apr. 15, 2001.
Kato, et al., Studies on Scavengers of Active Oxygen Species. 1. Synthesis and Biological Activity of 2-O-Alkylascorbic Acids,J. Med. Chem., 31:793-798 (1988).
Manfredini, et al., Novel Antiosidant Agents Deriving From Molecular Combinations of Vitamins C and E Analogues: 3,4-Dihydroxy-5(R)-[2(R,S)-(6-hydroxy-2,5,7,8-tetramethylchroman-2(R,S)-yl-methyl)-[1,3]dioxolan-4(S)-yl]-5H-furan-2-one and 3-O-Octadecyl Deerivatives,Bioorganic&Medical Chemistry, 8:2791-2801 (2000).
Manfredini, et al., Design, Synthesis and Activity of Ascorbic Acid Prodrugs of Nipecotic, Kinurenic and Diclophenamic Acids, Liable to Increase Neurotropic Activity,Journal of Medicinal Chemistry, (Nov. 2001).
Schwartz Elaine Benaksas
Wechter William J.
Dentz Bernard
Encore Pharmaceuticals, Inc.
Peters Verny Jones Schmitt & Aston, LLP
Verny Hana
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