R-(+) enantiomeric form of 7-(2, 3-epoxypropoxy) actinomycin D

Details R-(+) enantiomeric form of 7-(2, 3-epoxypropoxy) actinomycin D R-(+) enantiomeric form of 7-(2, 3-epoxypropoxy) actinomycin D

1991-08-19

1992-10-13

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530330, A61K 3702, C07K 500, C07K 700, C07K 1500

Patent

active

051552094

ABSTRACT:
The R-(+) enantiomeric form of .+-. racemic 7-(2, 3-empoxypropoxy) actinomycin D (EPA) is provided which is effective in the therapeutic treatment of cancer. The analogue has the formula: ##STR1## wherein the P's are: ##STR2## The enantiomeric form is uniformly superior to other forms of the compound in treating malignant tumors.

REFERENCES:
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Zbaida et al., Chemical Abstracts, 1988, CA108:94941f.
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Karrer, "Organic Chemistry" (Second English Ed.) N.Y., 1946, pp. 94-97.
Shafer et al., Biochemistry, vol. 21, 1982, pp. 6496-6503.
Barry, III, et al., Biochemistry, vol. 28, 1989, pp. 6323-6333.
Jeannesson et al., Cancer Research, vol. 50, Feb. 15, 1990, pp. 1231-1236.

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