R-diastereomer of an N.sup.6 -[(2-hydroxypropyl)aryl]adenosine a

Details R-diastereomer of an N.sup.6 -[(2-hydroxypropyl)aryl]adenosine a R-diastereomer of an N.sup.6 -[(2-hydroxypropyl)aryl]adenosine a

1988-10-26

1991-07-09

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 45, 536 26, 536 24, A61K 3170, C07H 19167

Patent

active

050306243

ABSTRACT:
A novel R diastereomer of an N.sup.6 -[(2-hydroxypropyl)aryl]adenosine, which diastereomer exhibits fewer CNS side effects than the racemate, but with no decrease in cardiovascular activity. The invention further provides for compositions incorporating the diastereomer, and methods of its use as well as pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 3502649 (1970-03-01), Thiel et al.
patent: 3551409 (1970-12-01), Kampe et al.
patent: 3590029 (1971-06-01), Koch et al.
patent: 3851056 (1974-11-01), Stork et al.
patent: 3929763 (1975-12-01), Fauland et al.
patent: 4340730 (1982-07-01), Henderson et al.
patent: 4388308 (1983-06-01), Hamilton et al.
Sollevi et al., Acta Physiol. Scand., 120, 171-176 (1984).
Kassell et al., J. Neurosurg., 58, 69076 (1983).

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