(R)-2-octanol dehydrogenases, methods for producing the...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

Reexamination Certificate

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C435S155000, C435S252300, C435S320100, C435S440000, C435S069100, C435S071100, C435S004000, C435S026000, C536S023200, C536S023740

Reexamination Certificate



This invention provides (R)-2-octanol dehydrogenase that catalyzes oxidation-reduction reaction using NAD+(NADH) as a coenzyme and the genes that encodes them. The enzymes of this invention can be obtained from microorganisms such as the generaPichia, Candida, andOgataea, and so on. It is possible to produce alcohols, in particular, alcohols such as (S)-4-halo-3-hydroxybutyric acid esters and (R)-propoxybenzene derivatives by reducing ketones with this (R)-2-octanol dehydrogenase. Moreover, the (R)-2-octanol dehydrogenase of this invention is excellent in activity and stereoselectivity.

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