R-(-)1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine, a process for

Details R-(-)1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine, a process for R-(-)1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine, a process for

1994-05-12

1995-12-26

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, C07D47306, A61K 3152

Patent

active

054788315

ABSTRACT:
R-(-)-1-(5-Hydroxyhexyl)-3-methyl-7-propylxanthine, a process for its preparation, and pharmaceuticals which contain this compound and which are suitable, in particular, for the prophylaxis and treatment of cerebral vascular disorders.

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Davis, P. J., et al., Mircobial Models of Mammalian Metabolism: Stereospecificity of Ketone Reduction with Pentoxifylline, Xenobiotica, vol. 15, No. 12, 1985, pp. 1001-1010.
Merete Ruud-Christensen et al., Separation of (R)-And (S)-proxyphylline As Diastereoisomeric Camphantes By Reversed-phase Liquid Chromotography, Journal of Chromatography 303 (1984) pp. 433-435.
Davis, P. J., et al., Microbial Models of Mammalian Metabolism: Microbial Reduction and Oxidation of Pentoxifyline, Applied and Environmental Microbiology, Aug. 1984, pp. 327-331, vol. 48, No. 2.
Merete Ruud-Christensen et al., Synthesis of (R)-and (S)-proxyphylline, 1984 Acta Chemica Scandinavica.
M. Christen et al., J. Chem Soc., Chem Comm. 264-44 (1988).
ATCC Catalogue of Yeasts at 71 (18th Ed., 1990).

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