R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine, a process fo

Details R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine, a process fo R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine, a process fo

1990-12-21

1995-04-18

Rizzo, Nicholas

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

544267, 514263, C07D47306, A61K 3152

Patent

active

054078156

ABSTRACT:
R-(-)-1-(5-Hydroxyhexyl)-3-methyl-7-propylxanthine, a process for its preparation, and pharmaceuticals which contain this compound and which are suitable, in particular, for the prophylaxis and treatment of cerebral vascular disorders.

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Christen et al J. Chem. Soc. Chem. Commun. pp. 264-266 (1988).
Merete Ruud-Christensen et al., Separation of (R)- And (S)-proxyphylline As Diastereoisomeric Camphantes By Reversed-phase Liquid Chromatography, Journal of Chromatography, 303 (1984) pp. 433-435.
Patrick J. Davis et al., Microbial Models of Mammalian Metabolism: Microbial Reduction and Oxydation of Pentoxifyline, Applied and Environmental Microbiology, Aug. 1984, pp. 327-331, vol. 48, No. 2.
Merete Ruud-Christensen et al., Synthesis of (R)- and (S)-proxyphylline, 1984 Acta Chemica Scandinavica.
David, P. J., et al.; Microbial Models of Mammalian Metabolism: Stereospecificity of Ketone Reduction with Pentoxifylline, vol. 15, No. 12, 1985, pp. 1001-1010.

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