Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-10-24
1989-12-12
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546153, 546159, 546167, 546168, 546176, 546177, 546178, 548229, 514313, 514312, A61K 3147, C07D41304
Patent
active
048868116
ABSTRACT:
This invention relates to novel quinolyloxazole-2-ones which are useful as protein kinase C inhibitors, effective in the treatment of hypertension and asthma. This invention also includes a novel procedure for producing an intermediate ketone compound involving the reaction of a bromo-quinoline compound with butyl lithium and further reacting the lithiated compound with N-methyl-N-methoxyalkanamide.
REFERENCES:
patent: 3025215 (1962-03-01), Gaertner
patent: 3857877 (1974-12-01), Somasekhara
patent: 4565820 (1986-01-01), Schnur et al.
patent: 4670450 (1987-06-01), Schnettler et al.
patent: 4673680 (1987-06-01), Pendleton
patent: 4681940 (1987-06-01), Musser et al.
patent: 4698353 (1987-10-01), Schnettler et al.
patent: 4728661 (1988-01-01), Schnettler
patent: 4738972 (1988-04-01), Eggler et al.
patent: 4751233 (1988-06-01), Clements-Jewery
Cheng Hsien C.
Claxton George P.
Dage Richard C.
Jones Winton D.
Robinson Phillip J.
Brewer Alice A.
Daus Donald G.
Merrell Dow Pharmaceuticals
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