Qunoline intermediates useful therein for synthesizing antibacte

Details Qunoline intermediates useful therein for synthesizing antibacte Qunoline intermediates useful therein for synthesizing antibacte

1990-04-27

1991-11-19

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

546 65, 546 90, 546 98, 546 99, 546100, 546123, 546156, 540476, 540479, 540559, 540586, 540576, 540219, 540221, 540224, 544247, 544250, 544252, 544300, 544310, 544316, 544317, 544318, 544319, 544320, 544321, 544324, 544327, 544328, 544331, 544333, 544361, 544405, C07D47106, C07D24500, C07D48706, C07D23928, C07D23900

Patent

active

050668005

ABSTRACT:
A novel process and intermediates used therein for linking a cephalosporin compound to a quinolone are disclosed. According to the disclosed process, the 2-carboxylic acid moiety of the cephalosporin compound is treated with an organic base. The resulting salt is then reacted with a quinolone compound which has been activated using a haloformate. The reaction is run in a non-aqueous organic solvent. 4-Dimethylaminopyridine is used to promote the reaction between the cephalosporin salt and the activated quinolone.

REFERENCES:
patent: 3532694 (1970-10-01), Somerfield

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