Quinuclidyl benzoxepins as 5-HT.sub.3 antagonists

Details Quinuclidyl benzoxepins as 5-HT.sub.3 antagonists Quinuclidyl benzoxepins as 5-HT.sub.3 antagonists

1988-02-04

1989-08-15

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514305, 546133, A61K 31625, C07D45302

Patent

active

048575178

ABSTRACT:
Certain specific substituted 9-N-(1-azabicyclo-[2.2.2.]octan-3-yl)carboxamido-2,3,4,5-tetrahydro-1-benz oxepins and their valuable use as 5-HT.sub.3 antagonists having CNS and gastric prokinetic acticity and void of any significant D.sub.2 receptor binding properties are disclosed. Methods for their preparation also are described.

REFERENCES:
patent: 3103515 (1963-09-01), Zaugg et al.

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