Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-08-01
1990-05-01
Rohman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514305, 546125, 546133, C07D45106, C07D45300, A61K 3146
Patent
active
049218603
ABSTRACT:
Pyridyl ethers of formula ##STR1## [where R is hydrogen, or 1 to 4 hydroxy, alkyl, alkoxy, amino, alkylamino, dialkylamino, halogen, trifluoromethyl, phenyl, halophenyl, alkyphenyl, alkoxyphenyl, carboxy, carboxamide, nitro, thiol or alkylthio substituents and B is quinuclidyl or tyopanyl] are useful for the treatment of conditions which respond to antagonism of 5 - HT.sub.3 receptors e.g. the treatment of migraine, emesis, anxiety, gastro-intestinal disorders and psychotic disorders.
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Tell et al., Proceedings of the BPS, p. 279P (Apr. 1984).
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Tyers et al., Neuroscience Letters Suppl. 29, S68 (1987).
Costall et al., Br. J. Pharmacol., 90, 89P (1987).
John Wyeth and Brother Limited
Rohman Alan L.
Seifert Arthur G.
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