Quinuclidinyloxy-isoxazole compounds and their therapeutic uses

Details Quinuclidinyloxy-isoxazole compounds and their therapeutic uses Quinuclidinyloxy-isoxazole compounds and their therapeutic uses

1992-08-27

1997-07-01

Wu, Shean C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546133, 546137, 514380, 548241, 548243, 548247, A61K 3142, A61K 3144, C07D45302, C07D26104

Patent

active

056439237

ABSTRACT:
Compounds of formula (I): ##STR1## wherein R.sup.1 is hydrogen, halogen or alkyl; R.sup.2 is hydrogen, alkyl, optionally substituted phenyl or a heterocycle; or R.sup.1 and R.sup.2 together form a group of formula --CR.sup.4 .dbd.CR.sup.5 --CR.sup.6 .dbd.CR.sup.7 --, where R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are hydrogen, halogen, alkyl group, alkoxy, halomethyl, alkylamino, dialkylamino, hydroxy, nitro, aliphatic carboxylic acylamino or amino; and R.sup.3 is piperidyl, substituted piperidyl or quinuclidinyl. The compounds are useful in the treatment and prophylaxis of cognitive disorders, notably senile dementia, including Alzheimer's disease. Processes for preparing the compounds are also provided.

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Chemical Abstracts vol. 68, No. 11, 11 Mar. 1968, p. 4788, abstract No. 49489j, Columbus, Ohio, US; K. Bowden et al.: "Synthesis of pantherine and related compounds" & J. Chem. Soc., C 1968, No. 2, pp. 172-185.
European Journal of Pharmacology vol. 130, Nos. 1/2, 1986, pp. 125-131; P. Sauerberg et al.: "Pharmacological profile of a novel class of muscarinic acetylcholine receptor agonists".
K. Bowden et al, "The Synthesis of Pantherine and Related Compounds", J. Chem. Soc. 1968, pp. 172-185.
Derwent Abstract of EP 458,214, 1991.

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