Quinuclidinic ester and derivatives of phenoxycarboxylic acids

Details Quinuclidinic ester and derivatives of phenoxycarboxylic acids Quinuclidinic ester and derivatives of phenoxycarboxylic acids

1981-03-19

1982-10-19

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

424253, 424263, 424266, 424267, 546137, C07D47308, C07D45302

Patent

active

043551661

ABSTRACT:
The invention relates to esters of 3-hydroxy-quinuclidine with phenoxycarboxylic acids, and their salts having general formula: ##STR1## wherein R.sub.1 represents H,CH.sub.3, and R.sub.2 represents H, Cl,Br or a radical of an acid of the group comprising oleic, pivalic, nicotinic, clofibric, pyridineacetic and teophyllineacetic acid.
The compounds of the invention jointly show hypocholesteremizing and hypotriglyceridimizing activity, combined with other therapeutically interesting properties, such as beta-blocking, diuretic, anti-inflammatory activity.
The invention furthermore relates to the pharmaceutical compositions containing the compounds of the invention as the active ingredients.

REFERENCES:
March, J., Advanced Organic Chemistry, McGraw Hill, New York, 1968, pp. 319-320.
Chemical Abstracts, 88: 37424j, (1978), [German Ols 2,713,596, Lafon, 10/13/77].
Mashkovsky, M., in Proc. Ist. Int. Pharm. Meeting, vol. 7, (Brunings, editor), Pergamon Press, Oxford, 1963, pp. 359-366.
Chemical Abstracts, 79: 53029d, (1973), [German Ols 2,250,327, Mieville, 4/26/73].

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