Quinuclidine derivatives and medicinal compositions...

Details Quinuclidine derivatives and medicinal compositions... Quinuclidine derivatives and medicinal compositions...

2006-09-19

2006-09-19

Aulakh, Charanjit S. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S137000, C548S454000, C548S452000, C514S413000, C514S414000

Reexamination Certificate

active

07109210

ABSTRACT:
Compounds of the formulawherein: {circle around (C)} is phenyl, C4to C9heteroaromatic, naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl or biphenyl;R1, R2and R3are hydrogen or a substituent;n is 0 to 4;A represents —CH2—, —CH═CR6, —CR6═CH—, —CR6R7—, —CO—, —O—, —S—, —S(O)—, SO2or —NR6—, wherein R6and R7are hydrogen or lower alkyl, or R6and R7together form an alicyclic ring;m is 0 to 8; (when m=0, A is not —CH2—);p is 1 or 2;B represents a group of the formula ii):wherein R10is hydrogen, hydroxy or methyl; andQ represents a single bond, —CH2—, —CH2—CH2—, —O—, —O—CH2—, —S—, —S—CH2— or —CH═CH—, andx represents an anion and wherein the compounds show high affinity for muscarinic M3receptors (Hm3).

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