Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-04-30
1999-08-17
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546133, C07D45300, C07D45302, A61K 3144
Patent
active
059394331
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is methoxy and R.sup.2 is selected from the group consisting of methyl, ethyl, isopropyl, sec-butyl and tert-butyl; and the pharmaceutically acceptable salts of such compounds.
These compounds are substance P antagonists and useful in the treatment of gastrointestinal disorders, inflammatory disorders, central nervous system disorders and pain.
REFERENCES:
patent: 5714496 (1998-02-01), Brown et al.
patent: 5716965 (1998-02-01), Ito et al.
patent: 5744606 (1998-04-01), Brieden
Ito Fumitaka
Kondo Hiroshi
Lowe, III John Adams
Nakane Masami
Rosen Terry Jay
DeBenedicts Karen
Ginsburg Paul H.
Pfizer Inc
Richardson Peter C.
Rotman Alan L.
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