Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-03-14
1997-06-24
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 79, 546 93, 546 94, A61K 3144, C07D45300, C07D45302, C07D22122
Patent
active
056417861
ABSTRACT:
Quinuclidine derivatives of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein m, P, Z, Y, R.sup.1, R.sup.2 and R.sup.3 are as defined below. The compounds are substance P antagonist and, therefore, are useful in treating gastrointestinal disorders, central nervous system disorders, inflammatory diseases, pain and migraine.
REFERENCES:
patent: 2455949 (1948-06-01), Rieveschl, Jr., et al.
patent: 4097528 (1978-06-01), Porta et al.
patent: 4246201 (1981-01-01), Borzatta
patent: 5422354 (1995-06-01), Lowe
Fuller Jr. Grover F.
Ginsburg Paul H.
Richardson Peter C.
Rotman Alan L.
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