Quinuclidine carbamate derivatives and their use as M3...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S135000, C546S137000

Reexamination Certificate

active

10404395

ABSTRACT:
A compound which is a carbamate of formula:wherein R1 representsR2 represents a benzyl, phenethyl, furan-2-ylmethyl, furan-3-ylmethyl, thiophen-2-ylmethyl or thiophen-3-ylmethyl group or a straight or branched alkyl group having 3 to 8 carbon atoms, an alkenyl group having 3 to 8 carbon atoms, or a cycloalkyl group of 3 to 6 carbon atoms; p is 1 or 2 and the substitution in the azoniabicyclic ring may be in the 2, 3 or 4 position including all possible configurations of the asymmetric carbons; or a pharmaceutically acceptable salt thereof. The pharmaceutically acceptable salt may be of formula:

REFERENCES:
patent: 2762796 (1956-09-01), Morel et al.
patent: 3714357 (1973-01-01), Gueremy et al.
patent: 6916828 (2005-07-01), Farrerons Gallemi et al.
patent: 2004/0063950 (2004-04-01), Farrerons Gallemi et al.
patent: 2004/0235887 (2004-11-01), Farrerons Gallemi et al.
patent: 2004/0266816 (2004-12-01), Albero et al.
patent: 2005/0043349 (2005-02-01), Catena Ruiz et al.
patent: 2155320 (1993-08-01), None
patent: 0 424 021 (1991-04-01), None
patent: 0 747 355 (1996-12-01), None
patent: 0 801 067 (1997-10-01), None
patent: 0 863 141 (1998-09-01), None
patent: 0 930 298 (1999-07-01), None
patent: 2 012 964 (1970-03-01), None
patent: 1 246 606 (1971-09-01), None
patent: 09-328469 (1997-12-01), None
patent: WO93/15080 (1993-08-01), None
patent: WO 01/04118 (2001-01-01), None
patent: WO 01/04118 (2001-01-01), None
patent: WO 02/00652 (2002-01-01), None
patent: WO02/051841 (2002-07-01), None
patent: WO 02/051841 (2002-07-01), None
patent: WO02/053564 (2002-07-01), None
patent: WO 2004/000840 (2003-12-01), None
patent: WO 2004/005285 (2004-01-01), None
van Zwieten et al. Cardiovascular drugs and therapy/sponsored by the International Society of Cardiovascular Pharmacotherapy, 1995, 9(1): 159-67.
Xu et al. Chemical & Pharmaceutical Bulletin, 1998, 46(2): 231-41.
Eglen, RM et al, Therapeutic opportunities from muscarinic receptor research, Trends in Pharm. Sci. 22(8), Aug. 2001, 409-414.
Wallis, RM et al, Muscarinic antagonists in te development for disorders of smooth muscle function, PMID: 10069502 (1999).
White, Muscarinic receptors in human airways, PMID: 7751523 (1995).
Brown, J.H. and Taylor, P. (2001). “Muscarinic Receptor Agonists and Antagonists,” Chapter 7In The Pharmacological Basis of Therapeutics. Goodman et al. eds., McGraw Hill: 10th edition, pp. 155-173.
Eglen, R.M. and Hegde, S. S. (1997). “Muscarinic Receptor Subtypes: Pharmacology and Therapeutic Potential,”Drug News Perspect.10(8): 462-469.
Konzett, H. and Rossler, R. (1940). “Versuchsanordnung zu Untersuchungen an der Bronchialmuskulatur,”Arch. Exp. Path. Pharmacol.195: 71-74.
Rang, H.P. et al. (1995). “Cholinergic Transmission,” Chapter 6In Pharmacology. Churchill Livingstone, New York, NY. 3rd Edition, pp. 117-147.
Ringdahl, R. et al. (1979).“Facile Preparation of the Enantiomers of 3-acetoxyquinuclidine and 3-quinuclidinol,”Acta Pharm. Suec.16:281-283.
Saraswati, M. et al. (1994). “Structure-Activity Studies of N,N-Dialkyl and Cycloalkyl Carbamate Esters of Dimethylethanolamine and Choline With Nicotinic and Muscarinic Cholinergic Properties,”Drug Development Research31: 142-146.
Shutske, G.M. (1990). “A Novel Synthesis of the Isoxazolo[5,4,3-kl]acridine Ring System,”J. Heterocyclic Chem.27: 1617-1621.
Waelbroeck, M. et al. (1990). “Binding of Selective Antagonists to Four Muscarinic Receptors (M1to M4) in Rat Forebrain,”Molecular Pharmacology.38: 267-273.
N.N. Godovikov, et al., “Synthesis and muscarinolytic activity of quinuclidinyl benzilate alkyl iodides”, Khim. Farm. Zh., vol. 19, No. 9, pp. 1060-1061, 1985.
J. Lars et al., “Some quinuclidine derivatives with potential antimalarial activity”,Acta Pharm. Suecica, vol. 5, pp. 71-76, 1968.
L. Noronha-Blob et al., “Stereoselective antimuscarinic effects of 3-quinuclidinyl atrolactate and 3-quinuclidinyl xanthene-9-carboxylate”,European Journal of Pharmacology, vol. 221, pp. 97-103, 1992.
S.H. Gao et al., “Stereochemistry of the Heterocyclic Alcohols Containing Piperidine Unit”,Chemical Journal of Chinese Universities, vol. 20, No. 2, pp. 232-236, 1999.
Fryer et al., Am. J. Respir. Crit. Care Med. 158:S154-S160 (1998).

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