Quinoxalinyl/quinoxalinylakyl-N- terminal cycloalkoxy-C- termina

Details Quinoxalinyl/quinoxalinylakyl-N- terminal cycloalkoxy-C- termina Quinoxalinyl/quinoxalinylakyl-N- terminal cycloalkoxy-C- termina

1992-07-16

1993-05-18

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544353, 544354, 544355, A61K 31495, C07D24146

Patent

active

052121747

ABSTRACT:
Non-peptidyl compounds characterized generally as quinoxalinyl/quinoxalinylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy .beta.-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ##STR1## wherein R.sub.1 is selected from ##STR2## wherein each of Y and Z is independently selected from hydrido, chloro, fluoro, methoxy and dimethylamino; wherein n is a number selected from zero through four, inclusive; wherein each of R.sub.2 and R.sub.4 is independently selected from hydrido and methyl; wherein R.sub.3 is methyl or ethyl; wherein R.sub.5 is cyclohexylmethyl; wherein R.sub.6 and R.sub.7 are taken together to form a partially saturated or fully saturated heterocyclic ring containing five to eight ring members with one or two ring members being oxygen atoms and the remaining ring members being carbon atoms, and which heterocyclic ring may be optionally substituted with lower alkyl; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 5037983 (1991-08-01), Sundeen et al.

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