Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-10-17
1998-03-03
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544354, A61K 31495, C07D24144
Patent
active
057234612
ABSTRACT:
Disclosed are quinoxalinone compounds of the formula I or Ia ##STR1## and physiologically tolerated salts and prodrugs thereof, in which n=zero, one or two;
REFERENCES:
Robert Ning et al., Quinazolines and 1,4-benzodiazepines. XLVI. Photochemistry of nitrones and oxaziridines, J. Heterocycl. Chem. (1970), 7(3), 475-8.
R. Ian Fryer et al., Synthesis of amidines from cyclic amides, J. Org. Chem. (1969), 34 (4), 1143-5.
A. Mederos et al., Polyaminocarboxylic acids with quinoxaline structure derived from o-diamines, An. Quim., Ser. B (1983), 79(3), 329-35.
N. Borthakur et al., Studies in 1, 2, 3, 4-tetrahydro-3-oxoquinoxaline-1-acetic acid: a facile oxidation of active methylene group, Indian J. Chem., Sect. B (1981), 20B(9), 822-4.
Yamamoto et al., JA-7008 422-R, (Mar. 26, 1970) 4-Acyl-3,4-dihydro-2(1H)-quinoxalinone derivatives having anti-inflammatory activity J3A.
Sumitomo Chem. Co., BE706,623 (Apr. 1, 1968) Quinoxalinones: Anti-inflammatory, Analgesic, Antipyretic.
Sankyo Co. Ltd., JA-7038639-R (Dec. 5, 1970), Suspension for Ming Tablets Prodn.
Sumitomo Chem. Co. Ltd., JA-7038700-R( Dec. 7, 1970), Novel 4-Acyl-3,4-Dihydro-2(1H) Quinoxaline Derivs Having Antinflammatory Antipyretic and Analgesic Activity.
Sankyo Co., Ltd., JA-7035800-R (Nov. 14, 1970), Coating Base Contg Polyvinylacetaldiethyl-Amino Acetate.
Takeda Chem. Ind. Ltd., JA-7035881-R (Nov. 16, 1970); Pelletization Process.
Sumitomo Chem. Co. Ltd., JA-7035903-R (Nov. 16, 1970); 4-Phenyl(or Furyl)-Alkan (or E)-Oyl-3,4Dihydro-Quinoxaline-2-Ones, Antifebrile, Anodyne.
Sumitomo Chem. Ind. Co. Ltd., JA-30509/69 (Apr. 11, 1966); (JA) as 23097/66 (Dec. 9, 1969), 4-Thienoyl-6(or Antiferbrile, Analgesic.
Sumitomo Chem. Co. Ltd., JA-1713/69 (Apr. 8, 1966); JA as 22375/66, (Jul. 29, 1969) 4-Acyl-3,4-Dihydro-2(1H)-Quinoxalinones.
Sumitomo Chem. Co. Ltd., JA-17137/69 (Apr. 11, 1966); JA as 23396/66; (Jul 29, 1969) Preparation of 4 (Opt, p.Subst. Denzohyl)-6 or 7 Subst.3,4-Dihydro-2(1H)-Quinoxalinone, Antiinflammatory.
EP 315959A; Novel quinoxaline derivs. useful as neurotropic agents.
U.S. 3,697,545 (Oct. 10, 1972); 9-Chloro-5-methylamino-2-phenyl-4H-1,3,6-benzoxadiazocine,--antiinflammato ry, anticonvulsant, and antibacterial agent.
Balzarini et al., "Resistance Pattern of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Quinoxaline S-2720," Dec. 1994, vol. 68, No. 12, pp. 7986-7992.
Balzarini et al., "Sensitivity of (138 GLU.fwdarw.LYS) Mutated Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase (RT) to HIV-1-Specific RT Inhibitors," Biochemical and Biophysical Research Communications, Jun. 1994, vol. 201, No. 3, pp. 1305-1312.
Elderfield, R.C., "Heterocyclic Compounds", The Quinoxalines, vol. 6, pp. 491-495, (1957).
Balzarini et al., Resistance Pattern of HIV, J. Virol., 68(12), 7986-92, 1994.
Ebbling, General Chemistry, fourth edition, pp. 991-992, 1993.
Kleim et al., Activity of a Novel Quinoxaline Derivative against HIV, Antimicrob. Agents Chemother., 37(8), 1659-64, 1993.
Kleim et al., Preclinical Evaluation of HBY 097, Antimicrob. Agents Chemother., 39(10), 2253-57, 1995.
Kleim et al., Mutational Analysis of Residue 190 of HIV, Virology, 200(2), 696-701, 1994.
Billhardt-Troughton Uta-Maria
Kirsch Reinhard
Kleim Jorg-Peter
Meichsner Christoph
Riess Gunther
Hoechst Aktiengesellschaft
McKane Joseph
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