Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1991-02-15
1992-06-02
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
544337, A61K 31675, C07F 96509
Patent
active
051186756
ABSTRACT:
The compounds of the formula: ##STR1## in which Q is the quinoxaline nucleus; m is one of the integers 0, 1 or 2; n is one of the integers 1,2 or 3; or a pharmaceutically acceptable salt, alkyl ester or ##STR2## where R.sup.3 and R.sup.4 are, independently, hydrogen, nitro, halo or methoxy, are NMDA antagonists useful in the treatment and prevention of central nervous system related pathological conditions resulting from overstimulation by excitatory amino acids.
REFERENCES:
patent: 4657899 (1987-04-01), Rzeszotarski et al.
patent: 4746653 (1988-05-01), Hutchison et al.
patent: 4888347 (1989-12-01), Woodruff et al.
Baudy Reinhardt B.
Greenblatt Lynne P.
Jirkovsky Ivo L.
American Home Products Corporation
Bernhardt E.
Jackson Richard K.
Shah Mukund J.
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