Quinoxaline compounds and their preparation and use

Details Quinoxaline compounds and their preparation and use Quinoxaline compounds and their preparation and use

1992-07-15

1994-05-03

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544345, C07D48704, A61K 31495

Patent

active

053088450

ABSTRACT:
Heterocyclic dihydroxyquinoxaline compounds having the formula ##STR1## wherein R.sup.1 is hydroxy; and R.sup.5 and R.sup.6 together form a fused phenyl, cyclohexyl or pyridyl ring, which is optionally substituted with halogen or CN; and R.sup.7 and R.sup.8 independently are hydrogen, hydroxy, NO.sub.2, halogen, CN, CF.sub.3, C.sub.1-4 - acetyl, SO.sub.2 NHCOCO.sub.2 Et, SO.sub.2 NR'R' or SO.sub.2 R', wherein R' is hydrogen or C.sub.1-4 -alkyl; or R.sup.5 and R.sup.6 independently are hydroxy, hydrogen, NO.sub.2, halogen, CN, CF.sub.3, C.sub.1-4 -alkoxy, acetyl, SO.sub.2 NHCOCO.sub.2 Et, SO.sub.2 NR'R' or SO.sub.2 R', wherein R' is hydrogen or C.sub.1-4 -alkyl; and R.sup.7 and R.sup.8 together form a fused phenyl, cyclohexyl or pyridyl ring which is optionally substituted with halogen or CN.

REFERENCES:
patent: 4889855 (1989-12-01), Jacobsen et al.
patent: 4912108 (1990-03-01), Jacobsen et al.
McFarlane et al., Tetrahedron Letts., vol. 28, No. 50, pp. 6363-6366 (1987).
Goldberg et al., Neuroscience Letters., vol. 23, pp. 187-191 (1981).
Benveniste et al., J. Neurochem., vol. 43, No. 5, pp. 1369-1374 (1984).
Davies et al., J. Physiol., vol. 297, pp. 621-635 (1979).
Turski et al., Neuroscience Letts., vol. 53, No. 3, pp. 321-326 (1985).

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