Quinone derivatives, their production and use

Details Quinone derivatives, their production and use Quinone derivatives, their production and use

1980-08-26

1983-06-14

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242484, 42424857, 424263, 424267, 424269, 424274, 424320, 424325, 424330, 424250, 536 24, 536 53, 542420, 542429, 542431, 542438, 542439, 544174, 560 8, 544377, 560100, 560104, 560126, 562443, 562507, 562510, 562556, 564 44, 564301, 564443, 564453, 544391, 546337, 548251, A61K 31495, C07D29518

Patent

active

043883125

ABSTRACT:
New quinone derivatives of the formula: ##STR1## wherein R.sup.1 is methyl or methoxy, or two of R.sup.1 combine to represent --CH.dbd.CH--CH.dbd.CH--, R is amino which may be substituted or --OR.sup.4 wherein R.sup.4 is hydrogen, C.sub.1-4 alkyl or --CH.sub.2 --CH.dbd.C(CH.sub.3 --CH.sub.2 --.sub.m H (wherein m is an integer of 1 to 10), and n is an integer of 1 to 10 when R is amino which may be substituted, or n is an integer of 2 to 10 when R is --OR.sup.4, and their hydroquinone forms, have useful physiological activities such as blood-pressure decreasing and antiallergic activities.

REFERENCES:
patent: 3562277 (1971-02-01), Hansen et al.
patent: 3728362 (1973-04-01), Morimoto et al.
patent: 3875163 (1975-04-01), Zumin et al.
patent: 3931257 (1976-01-01), Pawson
patent: 3950418 (1976-04-01), Bollag et al.
patent: 3957836 (1976-05-01), Morimoto et al.
patent: 4139452 (1979-02-01), Morimoto et al.
Brocklehurst, "Adv. Drug Res.", vol. 5, 1970, pp. 109-113.
Hanna, et al., "Nature", vol. 290, 1981, pp. 343-344.
Weiss, et al., "Science", vol. 216, 1982, pp. 196-198.

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