Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-02-25
1994-07-12
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
5483415, C07D21350, C07D23364
Patent
active
053290100
ABSTRACT:
The present invention is a quinone derivative which exhibits excellent therapeutic activity represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein A stands for a group represented by the formula: ##STR2## (wherein R.sup.3, R.sup.4 and R.sup.5 is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are each a lower alkoxy group
REFERENCES:
patent: 4851413 (1989-07-01), Terao et al.
Merck Index, 9th edition, 1976, #7770.
The Pharmacological Basis of Therapeutics, 8th Edition, Goodman & Gilman, pp. 1196 and 1457, 1990.
Journal of Medicinal Chemistry, vol. 34, No. 1, Jan. 1991, pp. 267-276, Ohkawa et al, "Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase, etc."
Patent Abstracts of Japan, vol. 9, No. 301 (C-316) Nov. 1985 and JP-A.noteq.40 139 646 (Ootsuka Seiyaki Koujiyou KK) Jul. 24, 1985, Abstract.
Abe Koichi
Harada Koukichi
Hibi Shigeki
Kawahara Tetsuya
Kobayashi Naoki
Eisai Co. Ltd.
Ivy C. Warren
M. Mach D. Margaret
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