Quinolyl organic germanium ester and the synthesis method...

Details Quinolyl organic germanium ester and the synthesis method... Quinolyl organic germanium ester and the synthesis method...

2005-06-09

2008-03-04

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S002000

Reexamination Certificate

active

07339063

ABSTRACT:
The present invention relates to compounds of quinolyl organic germanium ester having the following Formula 1 and the synthesis methods thereof. R1and R2are defined in the specification. Organic germanium acyl chloride and 8-hydroxylquinoline were used as the starting raw materials. Displacement reaction was carried out at 0-40° C., followed by hydrolysis reaction and then by changing the solvent, water soluble quinolyl organic germanium ester was finally obtained. The quinolyl organic germanium ester possesses better water solubility and fat solubility. Due to the existence of both drug active group (organic germanium part) and drug recognizing group (quinoline part) in the structure of the quinolyl organic germanium ester, the compound is expected to develop a novel kind of anti-tumor drug

REFERENCES:
patent: 1629166 (2005-06-01), None

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