Quinolonecarboxylic acid compounds and pharmaceutical use thereo

Details Quinolonecarboxylic acid compounds and pharmaceutical use thereo Quinolonecarboxylic acid compounds and pharmaceutical use thereo

1988-09-29

1989-12-26

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142222, 5142325, 544 586, 544 82, 544121, 544128, A61K 31535, C07D41304

Patent

active

048898570

ABSTRACT:
A quinolonecarboxylic acid compound of the formula: ##STR1## wherein R.sup.1 is an alkyl group, a cycloalkyl group, a haloalkyl group, an alkenyl group, mono- or di-alkylamino groups, a phenyl group or a phenyl group substituted by one to three substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxy group, a hydroxy group, a nitro group or an amino group, R.sup.2 is a hydrogen atom, an alkyl group, a cycloalkyl group, an acyl group or an alkoxycarbonyl group, R.sup.3 is a hydrogen atom, an alkyl group or an aralkyl group, or R.sup.2 and R.sup.3 together with the adjacent nitrogen atom form a heterocyclic ring, R.sup.4 is a hydrogen atom or an alkyl group, R.sup.5 is a hydrogen atom, an alkyl group, an aralkyl group or an ester residue which is readily hydrolyzable in vivo, X is a hydrogen atom, a halogen atom or an alkyl group, n is interger of 1 to 3, and a salt thereof, and pharmaceutical use thereof.
The compounds exhibit antibacterial activites and are useful for the treatment of various infectious diseases.

REFERENCES:
patent: 4382892 (1983-05-01), Hayakawa et al.
patent: 4556658 (1985-12-01), Grohe et al.
patent: 4665079 (1987-05-01), Culbertson et al.
patent: 4670444 (1987-06-01), Grohe et al.
patent: 4705788 (1987-11-01), Schriewer et al.
patent: 4753925 (1988-06-01), Grohe et al.

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