Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-12-18
1987-12-01
Marantz, Sidney
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546157, 546158, A61K 3147, C07D21518, C07D21522
Patent
active
047105070
ABSTRACT:
A heterocyclic-substituted 2-quinolone compound of the formula: ##STR1## or a pharmaceutically-acceptable salt thereof, wherein "Het" is an optionally substituted 5-or 6-membered monocyclid aromatic heterocyclic group attached by a carbon atom to the 5-, 6-, 7- or 8- position of the quinolone nucleus; R, which is attached to the 5-, 6-, 7- or 8- position, is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulphinyl, C.sub.1 -C.sub.4 alkylsulphonyl, halo, CF.sub.3, hydroxy, hydroxymethyl, or cyano; R.sup.1 is hydrogen, cyano (C.sub.1 -C.sub.4 alkoxy)carbonyl, C.sub.1 -C.sub.4 alkyl, nitro, halo, --NR.sup.3 R.sup.4 or --CONR.sup.3 R.sup.4 where each of R.sup.3 and R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl or R.sup.3 and R.sup.4 together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocyclic group optionally containing a further heteroatom or group selected from O, S and N--R.sup.5 where R.sup.5 is hydrogen or C.sub. 1 -C.sub.4 alkyl; R.sup.2 is hydrogen, C.sub.1 -C.sub.4 alkyl, or 2-hydroxyethyl; Y is hydrogen or C.sub.1 -C.sub.4 alkyl; and the dotted line between the 3- and 4- positions represents an optional bond. The compounds are inotropic agents useful as cardiac stimulants in the treatment of congestive heart failure.
REFERENCES:
patent: 3907808 (1975-09-01), Lesher
patent: 3962445 (1976-06-01), Buckle
patent: 3993656 (1976-11-01), Rooney
patent: 4258185 (1981-03-01), Nakao et al.
Tominaga, PCT/JP81/00328 (5/27/82).
Campbell Simon F.
Roberts David A.
Akers Lawrence C.
Benson Robert
Dryer Mark
Marantz Sidney
Pfizer Inc.
LandOfFree
Quinolone inotropic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Quinolone inotropic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinolone inotropic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1931609