Quinolone derivatives and their use in a method of controlling a

Details Quinolone derivatives and their use in a method of controlling a Quinolone derivatives and their use in a method of controlling a

1981-12-03

1983-06-28

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546153, A61K 3147, C07D21522

Patent

active

043905412

ABSTRACT:
Compounds of the following formula are described: ##STR1## in which n is 0, 1 or 2, R.sup.1 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl, trifluoromethyl, halo or nitro, and R.sup.2 and R.sup.3 are each independently hydrogen or C.sub.1-4 alkyl, and salts thereof. The compounds are useful in the treatment of immediate hypersensitivity conditions and are prepared by reaction of the appropriate formylquinolone with malonic acid, ylid or phosphonate.

REFERENCES:
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Narasimhan, et al., Synthesis, 1979, No. 11, pp. 903-906 (1979).
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Mosti, et al., Chemical Abstracts, vol. 90, 203917k (1979).
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Gyul'budagyan, et al., Chemical Abstracts, vol. 70, 106343z (1969).
Frank, et al., Chemical Abstracts, vol. 89, 75340g (1978).

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