Quinolone derivatives and salts thereof, preparation processes t

Details Quinolone derivatives and salts thereof, preparation processes t Quinolone derivatives and salts thereof, preparation processes t

1990-03-30

1992-10-06

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 5142288, 5142302, 5142335, 5142338, 514300, 514305, 540597, 544 96, 544101, 544362, 544363, 546123, 546136, 546156, A61K 3147, C07D40110, C07D40112, C07D41310

Patent

active

051532034

ABSTRACT:
Antibacterial quinolone derivatives represented by the following formula and salts thereof are disclosed. ##STR1## wherein R.sup.1 meawns a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted phenyl group, R.sup.2 denotes a hydrogen atom or a carboxyl-protecting group, R.sup.3 represents a hydrogen or halogen atom or an amino, mono- or di-(lower alkyl)amino, hydroxyl or lower alkoxyl group, X is a hydrogen or halogen atom, Y means a nitrogen atom or a group C-R.sup.4 in which R.sup.4 is a hydrogen or halogen atom or a lower alkyl or lower alkoxyl group or is a group ##STR2## which forms a ring together with R.sup.1 (i.e., the asterisked carbon atoms are linked to the N(1) atom of the quinolone skeleton), and A denotes a specific N-containing group. Preparation processes of the quinolone derivatives and antibacterial agents containing the same are also disclosed.

REFERENCES:
patent: 4473568 (1984-09-01), Hutt
patent: 4956465 (1990-09-01), Schriewer et al.
Hirai et al., Chemical Abstracts, vol. 113, No. 78184 (1990) (Abstract for JP 69478 Mar. 8, 1990).
Ziegler et la., Chemical Abstracts, vol. 112, No. 158016 (1990) (Abstract for J. Het. Chem. pp. 1141-1145, Apr. 1989).
Eoguet Ambros et al., Chemical Abstracts, vol. 111, No. 174004 (1989) (Abstract for ES 2003196, Oct. 16, 1988).
Ito et al., Chemical Abstracts, vol. 106, No. 67134 (1987) (Abstract of JP 61/218586 Sep. 29, 1986).
J. Heterocyclic Chem., (1989), 26, "Synthesis and Antibacterial Activity of Some 7-Substituted 1-Ethyl-6-Fluoro-1,4-Dihydro-4-. . . ", Ziegler et al.

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