Quinolone derivatives and antibacterial agents containing the sa

Details Quinolone derivatives and antibacterial agents containing the sa Quinolone derivatives and antibacterial agents containing the sa

1990-03-23

1993-09-14

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540597, 544349, 544105, 544363, 546 16, 546122, 546113, 546123, C07D40504

Patent

active

052450376

ABSTRACT:
Antibacterial quinolone derivatives represented by the following formula [I] and salts thereof are disclosed. ##STR1## wherein R.sup.1 means a hydrogen atom or a carboxyl-protecting group; R.sup.2 denotes a hydrogen or halogen atom or a hydroxyl, lower alkoxyl, amino, aralkylamino, or mono- or di-(lower alkyl)amino group; A represents an oxygen or sulfur atom or N--R.sup.3 in which R.sup.3 is a hydrogen atom or an amino-protecting group; X is a hydrogen or halogen atom; Y means a nitrogen atom or C--R.sup.4 in which R.sup.4 is a hydrogen or halogen atom or a lower alkyl or lower alkoxyl group; and Z denotes a halogen atom or a substituted or unsubstituted heterocyclic group having at least one nitrogen atom as a hetero atom.

REFERENCES:
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patent: 4786649 (1988-11-01), Ueda et al.
patent: 4801584 (1989-01-01), Yokose et al.
patent: 4851418 (1989-07-01), Sanchez
patent: 4962112 (1990-10-01), Rosen et al.
J. Med. Chem., 29. 394-404 (1986).
J. Med. Chem., 29. 2363-2369 (1986).
Chemical Abstracts vol. 105, No. 25, Dec. 22, 1986, p. 787, Abstract No. 226520t, Columbus, Ohio, US; & JP-A-61148179 (Kokai Tokkyo Koho) May 7, 1986 European Search Report.

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