Quinolone carboxylic acid--metal ion--acid complexes

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514191, 5142282, 5142352, 514254, 514255, 514314, 544 14, 544225, 544233, 546 2, 546 61, 546 64, A61K 3147, C07D21556

Patent

active

053345894

ABSTRACT:
Compositions of a quinolone carboxylic acids useful for oral or parenteral administration to a human or veterinary patient are disclosed which comprise quinolone carboxylic acid--metal ion--acid complexes in combination with a physiologically acceptable carrier and having a pH of about 4 to about 10, as well as a method for their production and use in treatment. Such compositions are found to cause unexpectedly low levels of vein irritation upon intravenous administration.

REFERENCES:
patent: 4705789 (1987-11-01), Grohe et al.
patent: 4730000 (1988-03-01), Chu
patent: 4808583 (1989-02-01), Grohe et al.
Nakano et al., Chem. Pharm. Bull. 26(5):1505-1510 (1978).

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