Quinolinyl/isoquinolinyl-terminated alkylamino ethynyl alanine a

Details Quinolinyl/isoquinolinyl-terminated alkylamino ethynyl alanine a Quinolinyl/isoquinolinyl-terminated alkylamino ethynyl alanine a

1993-09-13

1995-07-18

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514309, 514311, 514312, 546141, 546142, 546144, 546145, 546146, 546147, 546153, 546155, 546172, 546173, 546175, A61K 3147, C07D21514, C07D21716

Patent

active

054341620

ABSTRACT:
Compounds characterized as quinolinyl- or isoquinolinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension and are of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; X is selected from oxygen atom and methylene; G is a quinolinyl or isoquinolinyl group; R.sub.1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; R.sub.2 is phenylmethyl; each of R.sub.3 and R.sub.5 is hydrido; R.sub.4 is

REFERENCES:
patent: 4902706 (1990-02-01), Hanson et al.
patent: 5032577 (1991-07-01), Fung et al.
Umezawa et al, in J. Antibiot. (Tokyo), 23, 259-262 (1970).
Gross et al, Science, 175, 656 (1971).
Boger et al., Nature, 303, 81 (1983).
Kokubu et al, Biochem. Biophys. Res. Commun., 118, 929 (1984).
Castro et al, FEBS Lett., 167, 273 (1984).
Hanson et al, Biochm. Biophys. Res. Comm., 132, 155-161 (1985).

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