Quinolines and their therapeutic use

Details Quinolines and their therapeutic use Quinolines and their therapeutic use

2006-09-29

2010-12-28

Padmanabhan, Sreeni (Department: 1627)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S312000, C514S313000, C546S152000, C546S153000, C546S159000

Reexamination Certificate

active

07858640

ABSTRACT:
Compounds of formula [1] are CRTH2 antagonists, useful in the treatment of conditions having an inflammatory components; in which: R1-R9are various substituents; A is —CHR10—, —C(O)—, —S(O)n—, —O—, or —NR10— wherein n is an integer from 0-1 and R10is selected from various substituents; B is a direct bond or a divalent radical; R11and R12are selected from cvarious substituents; X is a carboxylic acid, tetrazole, 3-hydroxyisoxazole, hydroxamic acid, phosphinate, phosphonate, phosphonamide, sulfonic acid group, or a group of formula C═(O)NHSO2R6or SO2NHC(═O)R6; and Y is aryl, heteroaryl, aryl-fused-heterocycloalkyl, heteroaryl-fused-cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl group.

REFERENCES:
patent: 2004/0127708 (2004-07-01), Fuji et al.
patent: 0 101 330 (1984-02-01), None
patent: 0 556 060 (1993-08-01), None
patent: 1 413 306 (2004-04-01), None
patent: WO 03/066046 (2003-08-01), None
patent: WO 2004106302 (2004-05-01), None
Vippagunta et. al., Advanced Drug Delivery Reviews, 2001, Elsevier, vol. 48, pp. 3-26.
Lloyd, J. et al., “Quinoline-4-carboxylic acids as angiotensin II receptor antagonists,”Bioorganic&Medicinal Chemistry Letters, 1994, vol. 4, No. 1, pp. 195-200.

Affiliated with

Also associated with

Rating

Quinolines and their therapeutic use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Quinolines and their therapeutic use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinolines and their therapeutic use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4226495