Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-12-13
1992-04-21
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546156, C07D40110, A61K 3147
Patent
active
051068540
ABSTRACT:
Novel quinolonecarboxylic acids of the formula: ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl, R.sup.2 and R.sup.3 each is identically or differently hydrogen or C.sub.1 -C.sub.4 alkyl, R.sup.4 is cyclopropyl, phenyl, halo-phenyl, or thienyl optionally substituted by C.sub.1 -C.sub.4 alkyl or halogen, and R.sup.5 is halogen, or pharmaceutically acceptable salts thereof having a more potent and longer lasting antibacterial activities against G(+) and G(-) bacteria than known analogues, useful as antibacterial agents at an oral dose of 1-500 mg, preferably 50-100 mg per day to an adult.
REFERENCES:
patent: 4556658 (1985-12-01), Grohe et al.
patent: 4705788 (1987-11-01), Schriewer et al.
patent: 4771055 (1988-09-01), Domagala et al.
patent: 4927926 (1990-05-01), Corominas et al.
patent: 4990517 (1991-02-01), Petersen et al.
Okada Tetsuo
Sato Hisao
Tsuji Teruji
Datlow Philip
Shen Cecilia
Shionogi & Co. Ltd.
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