Quinolinecarboxylic acid derivatives as solubilized pro-drugs

Details Quinolinecarboxylic acid derivatives as solubilized pro-drugs Quinolinecarboxylic acid derivatives as solubilized pro-drugs

1991-03-18

1992-05-26

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 80, 534733, 544337, 546 23, 548111, 548336, A61K 31495, C07D40104

Patent

active

051168278

ABSTRACT:
The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.

REFERENCES:
patent: 4629728 (1986-12-01), Regnier et al.

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