Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1992-06-30
1993-03-02
Ford, John M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C07D51316, C07F 504
Patent
active
051910799
ABSTRACT:
Novel quinolinecarboxylic acid derivatives of the formula: ##STR1## wherein Z is ##STR2## in which R.sup.1 is hydrogen atom, a halogen atom, hydroxy or a lower alkyloxy; R.sup.2 is a halogen atom, hydroxy or a lower alkyloxy; R.sup.3 is a lower alkyl; and R.sup.4 is hydroxy or a di(lower alkyl)amino, and a pharmaceutically acceptable salt thereof, which have excellent antibacterial activities and are useful as an antibacterial agent, a pharmaceutical composition containing the same, and process for preparing the same.
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Proceeding of the 109th Annual Meetings of the Pharmaceutical Society of Japan, Nagoya 1989, vol. IV, p. 30 with English translation.
Kondo et al., Chemical Abstracts, vol. 114, entry 102051(g)(1991).
Nakanishi et al., "Mechanisms of Clinical Resistance to Fluoroquinolones . . .", Antimicrobial Agents and Chemotherapy, vol. 35, No. 12, pp. 2562-2567, Dec. 1991.
Shalit et al., "Widespread Quinolone Resistance Among Methicillin-Resistant . . . ", Antimicrobial Agents and Chemotherapy, vol. 33, No. 4, pp. 593-594, Apr. 1989.
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Inoue Yoshimasa
Jinbo Yoshikazu
Kondo Hirosato
Kotera Yasuo
Sakamoto Fumio
Ford John M.
Kanebo Ltd.
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