Quinoline therapeutic agents

Details Quinoline therapeutic agents Quinoline therapeutic agents

1987-05-11

1988-07-19

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514245, 514313, 544198, 544209, 544212, 544238, 544295, 544363, 546144, 546159, A61K 31495, C07D40104

Patent

active

047585684

ABSTRACT:
A series of novel 2-substituted 4-amino-6,7-dimethoxyquinoline derivatives have been prepared, including their pharmaceutically acceptable acid addition salts. These particular compounds are useful in therapy as highly potent antihypertensive agents. Preferred member compounds include 4-amino-2-[4-(2-furoyl)piperazin-l-yl]-6,7-dimethoxyquinoline, 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquin oline and 4-amino-6,7-dimethoxy-2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinol-2-yl)qu inoline, respectively. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
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patent: 3517005 (1970-06-01), Cronin et al.
patent: 3542785 (1970-11-01), Carney
patent: 3960861 (1976-06-01), Danilewicz et al.
patent: 4035367 (1977-07-01), Simpson
patent: 4188390 (1980-02-01), Campbell
patent: 4237135 (1980-12-01), Uno et al.
Chemical Abstracts, vol. 93, p. 671, Item No. 186404h (1980).

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