Quinoline or quinazoline derivatives, their production and use

Details Quinoline or quinazoline derivatives, their production and use Quinoline or quinazoline derivatives, their production and use

1997-10-21

1999-08-03

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514259, 544284, 546173, A61K 3147, A61K 31505, C07D23974, C07D21560

Patent

active

059325925

ABSTRACT:
A compound represented by the general formula: ##STR1## wherein Y represents a nitrogen atom or C-G (G represents a carboxyl group which may be esterified); ring R is a nitrogen-containing unsaturated heterocyclic group which may be substituted for; each of rings A and B may have a substituent; n represents an integer from 1 to 4; k represents the integer 0 or 1, or a salt thereof, which serves well as an anti-inflammatory agent, particularly a therapeutic agent for arthritis.

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Synthesis, Georg Thieme Publishers, pp. 718-719, (1979) (No. 9).
Anzini et al., "Synthesis and 5HT-Receptors Affinity of Some 4-Phenylquinoline Derivatives", Il Farmaco, vol. 44(6):555-563, (1989).
Anzini et al., "Synthesis And Benzodiazepine Receptors Affinity Of 3-Carbethoxy-4-Phenylquinoline Derivatives", Il Farmaco, vol. 47(2):191-202, (1992.
Alhaider et al., "Design, Synthesis, and Pharmacological Activities Of 2-Substituted 4-Phenylquinolines As Potential Antidepressant Drugs", J. Med. Chem., vol. 28:1394-1398, (1985).
Decision Making in Drug Research, (1983), pp. 173-188.
Pharmacologie, Ed. Frison-Roche/Slatkine, (1992), pp. 836, 544, 241, 74.

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