Quinoline intermediates of receptor tyrosine kinase...

Details Quinoline intermediates of receptor tyrosine kinase... Quinoline intermediates of receptor tyrosine kinase...

2005-01-14

2008-10-07

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S160000

Reexamination Certificate

active

07432377

ABSTRACT:
This invention is directed to methods of preparing 4-substituted quinoline compounds as intermediates in the manufacture of receptor tyrosine kinase inhibitors and intermediate compounds used in the methods thereof, wherein the 4-substituted quinoline compound has the following general formula (I):wherein substitutions at LG″, PG, A, G, R1and R4are set forth in the specification.

REFERENCES:
patent: 6297258 (2001-10-01), Wissner et al.
patent: 6617333 (2003-09-01), Rabindran et al.
patent: 7009053 (2006-03-01), Kim et al.
patent: 7126025 (2006-10-01), Considine et al.
patent: WO 98/43960 (1998-10-01), None
patent: WO 98/54158 (1998-12-01), None
patent: WO 00/18740 (2000-06-01), None
patent: WO 00/031049 (2000-06-01), None
patent: WO 00/68201 (2000-11-01), None
patent: WO 01/55116 (2001-08-01), None
patent: WO 02/36570 (2002-05-01), None
patent: WO 2005/070890 (2005-08-01), None
patent: WO 2006/117570 (2006-11-01), None
Tominaga et al., J. Heterocyclic Chem., 27, pp. 1217-1225 (1990).
Price and Boekelheide, “A Synthesis of Substituted 4-Aminoquinolines,” J. Am. Chem. Soc., vol. 68, pp. 1246-1250, 1946.
Meth-Cohn et al., “The Reverse Vilmeier Approach to the Synthesis of Quinolines, Quinolinium Salts and Quinolones”, Tetrahedron, vol. 51 (47), pp. 12869-12882, 1995.
R. M. Roberts and P. J. Vogt, J. Am. Chem. Soc., 78, 4778 (1956).
R. J. Jones, J. Am. Chem. Soc., 74, 4889 (1952).
U. Jordis, F. Sauter and M. Burkart, J. Prakt. Chem., 333 (2), 267 (1991).
H. Agui, T. Komatsu and T. Nakagome, J. Heterocyclic Chem., 12, 557 (1975).
H. Agui, T. Mitani, M. Nakashita and T. Nakagome, J. Heterocyclic Chem., 8, 357 (1971).
R.M. Roberts, J. Am. Chem. Soc., 71, 3848 (1949).
R.M. Roberts and R.H. DeWolfe, J. Am. Chem. Soc., 76, 2411 (1954).

Affiliated with

Also associated with

Rating

Quinoline intermediates of receptor tyrosine kinase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Quinoline intermediates of receptor tyrosine kinase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinoline intermediates of receptor tyrosine kinase... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3998766