Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-04-06
1986-08-19
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546157, A61K 3147, C07D21522
Patent
active
046070400
ABSTRACT:
Compounds of the formula: ##STR1## wherein A stands for --(CH.sub.2).sub.2 --, which may optionally bear one or two methyl substituents, or for --(CH.sub.2).sub.3 --, R.sup.1 stands for a defined (3-4C)alkyl radical, a cyclopropyl radical, or a phenyl radical which may optionally bear a defined substituent, and R.sup.2 and R.sup.3, which may be the same or different, stand for a methyl or ethyl radical, and pharmaceutically-acceptable acid-addition salts thereof. Process for the manufacture of said compounds. Pharmaceutical compositions comprising one of said compounds and a pharmaceutical diluent or carrier. The compounds are 5-hydroxytryptamine antagonists.
REFERENCES:
patent: Re16394 (1926-07-01), Callsen
patent: 1572768 (1926-09-01), Callsen
patent: 1860286 (1932-05-01), Hartmann
patent: 4035374 (1977-07-01), Durant et al.
patent: 4235909 (1980-11-01), Bach et al.
patent: 4260764 (1981-04-01), Johnson
patent: 4343805 (1982-08-01), Crossley et al.
patent: 4426387 (1984-01-01), Archibald et al.
patent: 4435405 (1984-03-01), Blackburn et al.
Gilman, et al., J. Am. Chem. Soc., vol. 71, pp. 3667-3668 (1949).
Westland, et al., J. Med. Chem., vol. 16(4), pp. 319-327 (1973).
Zayed, et al., Pharmazie, vol. 33(9), pp. 572-575 (1978).
Soc. Anon. pour l'Ind. a Bale, Chemical Abstracts, vol 26, 3624 (1932).
A. Wander A. G., Chemical Abstracts, vol 43, 7974e (1949).
Aryuzina, et al., Chemical Abstracts, vol 60, 7990f (1964).
Pettit, et al., Chemical Abstracts, vol. 61, 8271f (1964).
Pearce Robert J.
Thornber Craig W.
Daus Donald G.
Imperial Chemical Industries plc
Rivers Diana G.
LandOfFree
Quinoline derivatives which are 5-hydroxytryptamine antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Quinoline derivatives which are 5-hydroxytryptamine antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinoline derivatives which are 5-hydroxytryptamine antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-394147