Quinoline derivatives having VEGF inhibiting activity

Details Quinoline derivatives having VEGF inhibiting activity Quinoline derivatives having VEGF inhibiting activity

2001-08-08

2008-05-13

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S313000, C514S314000, C514S228200, C514S253060, C544S058200, C544S363000, C546S153000, C546S159000

Reexamination Certificate

active

07371765

ABSTRACT:
The invention relates to compounds of formula (I) wherein: either any one of G1, G2, G3, G4and G5is nitrogen and the other four are —CH—, or G1, G2, G3, G4and G5are all —CH—; Z is —O—, —NH—, —S—, —CH2— or a direct bond; Z is linked to any one of G1, G2, G3and G4; n is an integer from 0 to 5; m is an integer from 0 to 3; Rarepresents hydrogen or fluoro; Rb, R1and R2are defined herein and salt thereof, process for the preparation so such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and the use of a compound of formula I in the manufacture of a medicament for the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of diseases states including cancer and rheumatoid arthritis.

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