Quinoline derivatives for treating malaria

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5142352, 514253, 514256, 514314, 544128, 544238, 544333, 544405, 546163, A61K 3147, C07D21544

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active

059487917

ABSTRACT:
The invention relates to novel quinoline derivatives and their therapeutic use against malaria.

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patent: 2901484 (1959-08-01), Schock
patent: 5510356 (1996-04-01), Vennerstrom
Singh T et al. J. Med. Chem. 14 (4), 283-286, 1971.
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Goulding RW et al. J. Labelled compd. Radiopharm. 16 (1, secon Int. Symp. Radiopharm. Chem.), 46-48, 1979.
Jonathan L. Vennerstrom, et al., Journal of Medicinal Chemistry, vol. 35, No. 11, "Bisquinolines. 1. N,N-Bis(7-chloroquinolin-4-yl) alkanediamines with Potential against Chloroquine-Resistant Malaria" (1992), pp. 2129-2134.
Tara Singh, et al., Journal of Medicinal Chemistry, vol. 14, No. 4, "Antimalarials. 7-Chloro-4-(substituted amino) quinolines" (1971), pp. 283-286.
R.W. Goulding, et al., Chemical Abstract, vol. 92, No. 18031 "Radio-iodine labeled 4-amino-7-iodoquinolines for melanoma detection" (1980).

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