Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-03-07
2006-03-07
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S160000, C514S312000
Reexamination Certificate
active
07009053
ABSTRACT:
The present invention relates to new quinoline derivatives of formula (1) or their pharmaceutically acceptable salts with caspase-3 inhibitory activity and their preparation methods, wherein R2is H; halogen; C1-6alkyl; C1-6alkoxy; C1-6alkoxyalkyl; or C3-6cycloalkyl; R1is formula (a); —CN; or formula (b); R is H; C6-14aryl unsubstituted or substituted by halogen, C1-6alkyl, C1-6alkoxy or amino; 5–15 membered heterocyclic group unsubstituted or substituted by halogen, C1-6alkyl, C1-6alkoxy or amino; or —(CH2)n—CHR4R5. The present invention relates to a pharmaceutical composition for treating caspase-associated diseases by inhibiting the activity of caspase-3 which comprises the compound of formula (1) or its pharmaceutically acceptable salt.
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Jung Yoon Sung
Kim Sung-Gyu
Kong Jae Yang
Park Woo Kyu
Korea Research Institute of Chemical Technology
Lucas & Mercanti LLP
Seaman D. Margaret
Yungjin Pharmaceuticals Co., Ltd.
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